Medlife Deep Sleep with CBD

Description

Supplement Facts

Serving Size: 2 Capsules

Servings Per Container: 30

Calories …………………………………………..5

Magnesium Glycinate………………………….20mg

Reishi Mycelium/Beta/Glucans………………200mg

Lions Mane Mycelium/Beta/Glucans……….200mg

Passion Flower Extract (20.26%)…………….200mg

GABA (Gamma-Aminobutyric Acid)…………130mg

L-Theanine………………………..……………….50mg

Valerian Extract…..……………………………..150mg

Hops Flowers Extract……………………………50mg

Taurine……………………………………………..25mg

Ashwagandha…………………………………….25mg

Lemon Balm………………………………………25mg

CBD………………………………………………..20mg  (THC Content: < 0.001%)

GMO FREE

Our Deep Sleep Formula is a carefully balanced blend of clinically studied natural compounds, botanicals, adaptogens, and neuroactive nutrients designed to promote restful sleep, reduce sleep latency, and support a calm nervous system.

Magnesium Glycinate (20mg) serves as a foundational mineral in this blend, playing a critical role in calming the nervous system and enhancing sleep quality by acting as a cofactor for GABA receptors—the brain’s primary inhibitory neurotransmitter [1]. The glycine component itself may contribute to improved sleep efficiency and reduced nighttime awakenings [2].

Central to this formula is Reishi (Ganoderma lucidum) mycelium and beta-glucans (200mg), a revered adaptogenic mushroom known for its sedative and anxiolytic properties. Preclinical studies have shown that Reishi extracts promote non-REM sleep and reduce sleep latency, possibly via modulation of GABAergic and serotonergic systems [3,4].

Lion’s Mane (Hericium erinaceus) mycelium and beta-glucans (200mg) adds a neuroregenerative aspect to the blend. While traditionally used for cognitive enhancement, recent studies suggest that Lion’s Mane may also alleviate anxiety and improve sleep quality through its effects on nerve growth factor (NGF) and hippocampal neurogenesis [5,6].

To support natural calm and help reduce hyperactivity in the brain, the formula includes GABA (Gamma-Aminobutyric Acid) (130mg), which plays a direct role in promoting relaxation by reducing neuronal excitability [7].

This effect is synergistically enhanced by L-Theanine (50mg), an amino acid found in green tea that has been shown to increase alpha brainwave activity associated with calm alertness, reduce stress, and improve sleep quality without causing drowsiness [8].

Passion Flower extract (200mg at 20.26% standardization) contributes natural flavonoids like vitexin and chrysin, which modulate GABAergic activity and have been clinically linked to improvements in sleep latency and sleep maintenance in people with mild insomnia [9,10].

Valerian root extract (150mg), long used as a herbal sleep aid, has demonstrated efficacy in reducing the time to fall asleep and enhancing deep sleep stages, likely by inhibiting GABA breakdown [11].

Additionally, Hops flower extract (50mg), often used in synergy with valerian, supports sedation and deep sleep, possibly through adenosine and melatonin receptor interactions [12].

Taurine (25mg), a sulfur-containing amino acid, helps modulate neuronal excitability and has been found to activate GABA-A receptors, making it a supportive agent for calming overactive brain activity [13].

To buffer stress and promote hormonal balance, we include Ashwagandha (Withania somnifera) (25mg), a well-known adaptogen with clinically documented benefits in reducing cortisol levels and improving sleep quality, especially in people with stress-related insomnia [14,15].

Lemon Balm (Melissa officinalis) (25mg), another calming botanical, has been shown to reduce anxiety, restlessness, and improve subjective sleep quality through its action on GABA transaminase [16].

Finally, CBD (Cannabidiol) at 20mg (with ultra-low THC content <0.001%) adds powerful anti-anxiety, anti-inflammatory, and neuroregulatory effects. Preliminary research suggests CBD may improve sleep duration, reduce nightmares in PTSD, and modulate cortisol secretion at night—supporting both sleep onset and quality [17,18].

References

1. Wienecke, E. et al. (2016). Magnesium and sleep regulation. Nutrients.

2. Yamadera, W. et al. (2007). Glycine ingestion improves sleep quality. Sleep and Biological Rhythms.

3. Chen, N. et al. (2012). Sedative effects of Ganoderma lucidum. Journal of Ethnopharmacology.

4. Gao, Y. et al. (2003). Ganoderma lucidum in insomnia and fatigue. Phytotherapy Research.

5. Mori, K. et al. (2009). Neurogenesis promotion by Lion’s Mane. Biomedical Research.

6. Nagano, M. et al. (2010). Lion’s Mane reduces depression and anxiety. Biomedical Research.

7. Abdou, A. et al. (2006). GABA ingestion and relaxation. BioFactors.

8. Kimura, K. et al. (2007). Theanine effects on stress and sleep. Biological Psychology.

9. Ngan, A. & Conduit, R. (2011). Passionflower improves sleep quality. Phytotherapy Research.

10. Dhawan, K. et al. (2004). Flavonoids in Passiflora species. Journal of Ethnopharmacology.

11. Fernandez-San-Martin, M. et al. (2010). Valerian in insomnia: meta-analysis. Sleep Medicine.

12. Schmitz, M. et al. (2006). Hops and valerian improve sleep latency. Fitoterapia.

13. El Idrissi, A. (2008). Taurine regulation of GABA receptors. Neurochemical Research.

14. Chandrasekhar, K. et al. (2012). Ashwagandha reduces cortisol and improves sleep. Indian Journal of Psychological Medicine.

15. Langade, D. et al. (2019). Ashwagandha for stress and sleep. Cureus Journal of Medical Science.

16. Cases, J. et al. (2011). Melissa officinalis and mood disorders. Mediterranean Journal of Nutrition.

17. Shannon, S. et al. (2019). Cannabidiol in anxiety and sleep: case series. The Permanente Journal.

18. Babson, K. et al. (2017). Cannabis, cannabinoids, and sleep: review of literature. Current Psychiatry Reports.

DISCLAIMER: This product may be a complementary medicine and/or not have been evaluated and verified by the South African Health Products Regulatory Authority for its quality, safety or intended use. Use of this product is therefore not intended to compensate for diagnosis, treatment, cure, or mitigation of medical conditions and must not substitute the obtaining of medical advice from a registered health professional for any health or health-related conditions.